Patterson and Grabenstein team up once again and bring young readers a story about a small mouse with a big personality. Isaiah is a special kind of mouse: he can read, write and talk to humans, too! When he is separated from his very large family, he relies on the friendships that he makes along the way to get him through this tough time. The most special friend he makes is an equally lonely human girl named Hailey, and the two become inseparable. Will Isaiah be able to reconnect with his family or will they be gone for good?